Investigating non-susceptibility contributions to GRE phase contrast


Journal article


K. Sommer, F. Schweser, A. Deistung, J. Reichenbach
2011

Semantic Scholar
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Cite

APA
Sommer, K., Schweser, F., Deistung, A., & Reichenbach, J. (2011). Investigating non-susceptibility contributions to GRE phase contrast.

Chicago/Turabian
Sommer, K., F. Schweser, A. Deistung, and J. Reichenbach. “Investigating Non-Susceptibility Contributions to GRE Phase Contrast” (2011).

MLA
Sommer, K., et al. Investigating Non-Susceptibility Contributions to GRE Phase Contrast. 2011.


Abstract

INTRODUCTION – Quantitative susceptibility mapping (QSM) is a novel imaging technique that determines tissue magnetic susceptibility from conventional gradientecho (GRE) phase images. While it has been shown that the main part of phase contrast can be explained by the bulk magnetic susceptibility (BMS) of tissue [1], the requirement for strong regularization during reconstruction indicates that non-BMS contributions are present in the phase images. This is confirmed by recent investigations that suggest that local non-BMS effects, such as chemical exchange between water and macromolecules [2] or a non-spherical Lorentzian cavity [3], contribute to phase contrast between gray and white matter. In this contribution, we present a technique for separating BMS and non-BMS effects in phase data and, as a proof-of-principle, demonstrate it with an initial experiment based on simulated data.