Journal article
F. Schweser, M. Dwyer, A. Deistung, J. Reichenbach, R. Zivadinov
Front. Physics, 2013
Front. Physics, 2013
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APA
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Schweser, F., Dwyer, M., Deistung, A., Reichenbach, J., & Zivadinov, R. (2013). Impact of tissue atrophy on high-pass filtered MRI signal phase-based assessment in large-scale group-comparison studies: a simulation study. Front. Physics.
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Schweser, F., M. Dwyer, A. Deistung, J. Reichenbach, and R. Zivadinov. “Impact of Tissue Atrophy on High-Pass Filtered MRI Signal Phase-Based Assessment in Large-Scale Group-Comparison Studies: a Simulation Study.” Front. Physics (2013).
MLA
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Schweser, F., et al. “Impact of Tissue Atrophy on High-Pass Filtered MRI Signal Phase-Based Assessment in Large-Scale Group-Comparison Studies: a Simulation Study.” Front. Physics, 2013.
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@article{f2013a,
title = {Impact of tissue atrophy on high-pass filtered MRI signal phase-based assessment in large-scale group-comparison studies: a simulation study},
year = {2013},
journal = {Front. Physics},
author = {Schweser, F. and Dwyer, M. and Deistung, A. and Reichenbach, J. and Zivadinov, R.}
}
Abstract
The assessment of abnormal accumulation of tissue iron in the basal ganglia nuclei and in white matter plaques using the gradient echo magnetic resonance signal phase has become a research focus in many neurodegenerative diseases such as multiple sclerosis or Parkinson’s disease. A common and natural approach is to calculate the mean high-pass-filtered phase of previously delineated brain structures. Unfortunately, the interpretation of such an analysis requires caution: in this paper we demonstrate that regional gray matter atrophy, which is concomitant with many neurodegenerative diseases, may itself directly result in a phase shift seemingly indicative of increased iron concentration even without any real change in the tissue iron concentration. Although this effect is relatively small results of large-scale group comparisons may be driven by anatomical changes rather than by changes of the iron concentration.