Teriflunomide's Effect on Glia in Experimental Demyelinating Disease: A Neuroimaging and Histologic Study


Journal article


Suyog U. Pol, M. Sveinsson, Michelle L. Sudyn, Natan Babek, Danielle Siebert, N. Bertolino, C. Modica, Marilena Preda, F. Schweser, R. Zivadinov
Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2018

Semantic Scholar DOI PubMed
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APA
Pol, S. U., Sveinsson, M., Sudyn, M. L., Babek, N., Siebert, D., Bertolino, N., … Zivadinov, R. (2018). Teriflunomide's Effect on Glia in Experimental Demyelinating Disease: A Neuroimaging and Histologic Study. Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging.

Chicago/Turabian
Pol, Suyog U., M. Sveinsson, Michelle L. Sudyn, Natan Babek, Danielle Siebert, N. Bertolino, C. Modica, Marilena Preda, F. Schweser, and R. Zivadinov. “Teriflunomide's Effect on Glia in Experimental Demyelinating Disease: A Neuroimaging and Histologic Study.” Journal of neuroimaging : official journal of the American Society of Neuroimaging (2018).

MLA
Pol, Suyog U., et al. “Teriflunomide's Effect on Glia in Experimental Demyelinating Disease: A Neuroimaging and Histologic Study.” Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging, 2018.


Abstract

Teriflunomide reduces disability progression and brain atrophy in multiple sclerosis patients. The exact mechanism of action by which teriflunomide exerts these effects is currently unknown. We assessed the effect of teriflunomide on brain glial cells in the Theiler's murine encephalomyelitis virus (TMEV) by using a histological approach in combination with neuroimaging.