Investigation of the cellular and molecular substrate of brain iron changes


We are conducting an investigation into how Multiple Sclerosis (MS) affects the cellular and molecular distribution of iron in the brain, and how these changes are reflected in clinical iron metrics on Magnetic Resonance Imaging (MRI). To this end, we are studying how MS alters the density and iron load of different cell types across brain regions, and how these alterations are related to markers of inflammation. Our research seeks to provide a better understanding of the effects of MS on the brain, and how this can be used to inform diagnosis and treatment.
Our research has the potential to significantly contribute to the development of novel and much-needed therapeutic interventions for neurological diseases. This is because it provides a greater understanding of the role of iron dyshomeostasis in neurological diseases, as well as the biological correlates of clinical findings that can be identified through iron-sensitive MRI techniques. With this knowledge, we can work towards developing more effective treatments for neurological diseases.

Publications


Is iron the source of post mortem susceptibility contrast in the brain ?


F. Schweser, C. Langkammer, A. Deistung, N. Krebs, W. Goessler, E. Scheurer, K. Yen, F. Fazekas, J. Reichenbach, S. Ropele


2010


Quantitative susceptibility mapping (QSM) as a means to measure brain iron? A post mortem validation study


C. Langkammer, F. Schweser, N. Krebs, A. Deistung, W. Goessler, E. Scheurer, K. Sommer, G. Reishofer, K. Yen, F. Fazekas, S. Ropele, J. Reichenbach


NeuroImage, 2012


Embedding medium alters local phase contrast in postmortem MRI of the human brain


Schweser F, Hametner S, Jochmann T, Riedl C, Bachrata B, Laux M, Grabner G


Joint Workshop on MR phase, magnetic susceptibility and electrical properties mapping, Lucca, Italy, 2022